Shooting .22 will make you work a little harder on your range-finding. But it does have the added bonus of a giant splat on the plate letting you know where you went wrong.
Personally I have medium one-piece mounts and I'm zero'ed to 15-20yards, every half dot is a further five yards. For the short ones just put the crosshairs at the top of the kill and the pellet will rise up into the kill.
Works great for UKAHFT rules courses, but sometimes a little tricky with extreme shoots: "Let me see now, I'm guessing 65yards is four and a half dots